is retroviral hypodysplasia a real disease10 marca 2023
is retroviral hypodysplasia a real disease

Renal ultrasound studies on both parents and a surviving child were normal. Osborn is dying from a degenerative disease called retroviral hypodysplasia which has caused him to mutate and eventually leads to his death. Note: Erratum: Am. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Brit. The parents were unrelated. [Full Text], Humbert, C., Silbermann, F., Morar, B., Parisot, M., Zarhrate, M., Masson, C., Tores, F., Blanchet, P., Perez, M.-J., Petrov, Y., Khau Van Kien, P., Roume, J., and 9 others. This is important because the virus easily mutates, which can make it resistant to certain medications. Familial aggregation in bilateral renal agenesis. [PubMed: 7151297] 60: 1-8, 1934. What is the worst/ silliest move 'illness'? Ale odhlen nkterch z tchto soubor cookie me ovlivnit v zitek z prohlen. Hack et al. Schmidt et al. Maughan A(1), Sadigh K(2), Angulo-Diaz V(2), Mandimika C(1), Villanueva M(1), Lim JK(3), Ogbuagu O(4). HIV is a retrovirus. Table of Contents. In lithium-ion batteries the ones from your cell phone its the cobalt oxide inside that can suffer from thermal runaway that eventually leads to explosion or rupture. Za tu dobu jsme nasbrali adu cennch zkuenost. Soubor cookie se pouv k uloen souhlasu uivatele s pouvnm soubor cookie v kategorii Analytika. Bilateral absence of renal tissue and very low volume of amniotic fluid were the basis of the diagnosis. [Full Text], Roodhooft, A. M., Birnholz, J. C., Holmes, L. B. Schmidt et al. Pediat. S fortelem. 11-13 Harry was now Oscorp's CEO and was soon reunited with his childhood friend. Pouvme tak soubory cookie tetch stran, kter nm pomhaj analyzovat a porozumt tomu, jak tento web pouvte. (1987) reported bilateral renal aplasia in 3 consecutive sibs. That DNA can then integrate into the host cells DNA. Theres plenty of examples of viruses picking up human genes, but this is one of the first examples of the reverse.. Joss et al. Covering the hottest movie and TV topics that fans want. Nicholas Brooks has been writing professionally for over a decade, covering many aspects of pop culture from film and video games to comics and anime. Inductive interactions between the ureteric epithelium and metanephric mesenchyme are essential for kidney morphogenesis. Iron Man is a punching machine, and now we have the numbers to prove it, 'Search for Planet X' board game simulates real astronomy. gag [Full Text], Selig, A. M., Benacerraf, B., Greene, M. F., Garber, M.-F., Genest, D. R. What we used to think of as junk DNA is actually modulating our development.. CNV distribution was significantly skewed toward larger gene-disrupting events in RHD cases compared to 4,733 ethnically matched controls (p = 4.8 x 10(-11)). A., Bower, R. WebWhy was Retroviral Hypodysplasia (goblin disease) killing Harry faster than Norman in The Amazing Spider-man 2? It blocks the receptors that the virus uses to enter the cell so it cant get in. Humbert et al. Edith Potter (1901-1993). J. Med. Copy-number disorders are a common cause of congenital kidney malformations. The results of ACTG 175 and CPCRA 007, as well as other studies, indicated that prior antiretroviral experience can profoundly Viral load monitoring is an important factor in managing HIV disease. in 2000 [Full Text], Carter, C. O., Evans, K., Pescia, G. (2014) noted that Itga8-null mice also display renal agenesis (Muller et al., 1997), further supporting the findings in these families. 67: 667-670, 1954. Spider-Mans last, desperate gambit to lay low his supercharged foe, Electro, hinges on the idea that batteries can explode when overcharged. They comprise HIV-I, HIV-2, and AIDS. In order to let a fetus mature inside a mothers uterus, an animal needed a way to provide oxygen and nutrients while removing waste and keeping both blood supplies separate. Madisson, H. [PubMed: 4413435] Infectious Disease Epidemiology, Prevention and Control Division, Health Care Facilities, Providers, and Insurance, Healthy Communities, Environment, and Workplaces, Retroviruses That May Cause Human Illness, Other Retroviruses that may cause human illness, Communicable Disease Reporting Rules, Chapter 4605, Minnesota Family Planning and STD Hotline. Vkonnostn cookies se pouvaj k pochopen a analze klovch vkonnostnch index webovch strnek, co pomh pi poskytovn lep uivatelsk zkuenosti pro nvtvnky. They are still evolving, just as we are, Feschotte says. You can clearly see the pattern of expression of these genes, but their actual role still remains to be established, he says. Neukld dn osobn daje. One of the few survivors of the asteroid impact 65 million years ago was a small, furry, shrew-like creature that lived in underground burrows and only ventured out at night, when predators werent active. 5: 173-177, 1974. Besides human immunodeficiency Gynec. Schmidt et al. Baron (1954) described bilateral agenesis of the kidneys in 2 consecutive infants in a family. The more we look, the more we find overlap,. , were completely non-functional, McCoy says. Healthline Media does not provide medical advice, diagnosis, or treatment. Psychic predictions: stunning research results revealed, [Sundance 23] Infinity Pool review: Grotesquely beautiful and hedonistic ride, X-Men Monday #189 Benjamin Percy Talks X-Force, Wolverine, and Ghost Rider/Wolverine: Weapons of Vengeance. Next Level Racing F-gt Monitor Stand, Malm i vtm investorm nabzme monost zajmav zhodnotit penze. The characteristic phenotype of these infants is independent of the origin of the renal abnormality and results from the decreased volume of amniotic fluid and consequent restricted fetal movement. 22: 105-127, 1982. Madisson (1934) reported bilateral renal agenesis in sibs. 153: 471, 1994. 73: 278-280, 1984. Med. Because the introduction of the retrovirus was still so new, the virus hasnt accumulated many mutations, and the koalas genetic machinery still actively turns the viral DNA into active virus. Retroviruses are a family of viruses that are grouped together based on how they are structured and how they replicate within a host. 72: 88-93, 1968. Neizen. Ravinder Kanda, a paleovirologist at the Oxford Brooks University in the U.K., says that those sheep that carry a copy of the retroviral DNA are immune to infection from the circulating retrovirus. 91: 987-997, 2012. Humans are, in a very real sense, part virus. (1982) reported prenatal diagnosis of kidney diseases by ultrasonography in 23 families. [PubMed: 4413435, related citations] Li et al . , published in early 2016, found another, HERV-H, which produced RNA molecules that also switch other genes on and off. Tyto soubory cookie anonymn zajiuj zkladn funkce a bezpenostn prvky webu. While the OMIM database is open to the public, users seeking information about a personal Major funding for NOVA is provided by the NOVA Science Trust, the Corporation for Public Broadcasting, and PBS viewers. By turning the rheostat a bit, by changing the timing, you can actually change development dramatically, Reijo Pera says. All was going as planned until McCoys bioinformatics specialist Steve Howes rushed into his lab in 1997 to show him the sequence of a gene they called syncytin, which their work showed was secreted by placenta tissue. Want to take our relationship to the next level? Disruption of normal renal development can lead to congenital anomalies of the kidney and urinary tract (CAKUT), including renal hypodysplasia, which is characterized by Science 1 What is genacol? Clinically known as Retroviral Hypodysplasia, the Osborn Curse has no actual diseases to base it on. Reality Check Real Madrid Vs Bayern Munich 2018, This excess was attributable to known and novel (i.e., not present in any database or in the literature) genomic disorders. J. Med. One answer may come from another retrovirus that plagues domestic sheep, creating an infectious form of lung cancer. Due to a recessive gene called 'retroviral hypodysplasia' passed on from his father, harry quickly began to succumb to a disease that turned some of his skin green and Am. Hypodysplasia is a term that just means something didnt form properly, and can be applied to anything from teeth to your kidneys. Funkn soubory cookie pomhaj provdt urit funkce, jako je sdlen obsahu webovch strnek na platformch socilnch mdi, shromaovn zptn vazby a dal funkce tetch stran. 15: 314-316, 1978. Retroviruses, however, use a slower, stealthier approach. All rights reserved. Unable to accept this, Richard added his own DNA to the spiders', ensuring the formula that could cure Osborn could never be replicated or used. For a possible association between renal hypodysplasia/aplasia and variation in the SLIT3 gene, see 603745.0001. WebRetroviral Hypodysplasia is a rare, genetic, incurable fictional disease. Bact. 16: 176-188, 1979. All the latest gaming news, game reviews and trailers. J. Med. It can pass the hybrid genome on to its offspring, creating what scientists call a fully endogenous retrovirusa fancy term for a virus that comes from within. Integrin alpha 8 recessive mutations are responsible for bilateral renal agenesis in humans. Where we succeeded, where we didn't, and what we learned. "Retroviral Hypodysplasia. [PubMed: 3886908, related citations] Whatever the hell Electro is, hes not a battery. Less is known about HTLV2, which is mostly found in North, Central, and South America. Genet. Budeme rdi, kdy se k nm pidte S nmi vedle nelpnete. We launched Retroviral as a hybrid agency in 2010, with a focus on digital / PR / activation. [Full Text: https://doi.org/10.1016/s0022-3476(73)80324-5]. The late University of Massachusetts researcher believed that cooperation also played a role. In the films, the condition is tied to the Osborn family and slowly ravages the body before leaving the person in a state where they are in constant pain and env The work is still preliminary, says virologist John Coffin at Tufts University, who has spent much of his long career studying retroviruses, including endogenous retroviruses. Viral proteins already have functions. They definitely are., Photo credit: Scientific Director, OMIM. Mete vak navtvit Nastaven soubor cookie a poskytnout kontrolovan souhlas. Nor was syncytin the only driver. Both infants showed typical Potter facies with pulmonary hypoplasia and died soon after birth. Bilateral agenesis of the kidneys in two consecutive infants. HTLV1 is found mostly in Japan, the Caribbean, and parts of Africa. 7: 573-579, 1987. ; ; our revenue stream. [PubMed: 712765] Reality Check: The conspiracy theories around Sandy Hook, and other school shootings, Reality Check: 'The Department of Truth' finally faces QAnon. [Full Text: https://doi.org/10.1002/ajmg.1320290336], Baron, C. Renal hypodysplasia/aplasia belongs to a group of perinatally lethal renal diseases, including bilateral renal aplasia, unilateral renal agenesis with contralateral dysplasia (URA/RD), and severe obstructive uropathy. (1988) cautioned that renal ultrasound examination of parents of offspring with perinatal lethal renal disease cannot be depended on to exclude the presence of a genotype that could lead to recurrence in a later-born sib. On the other hand, endogenous retroviruses have also been blamed for certain kinds of cancer. Edith Potter (1901-1993). 94: 288-294, 2014. (2012) examined the burden of large rare copy number variants (CNVs) in 192 individuals with renal hypodysplasia (RHD), including renal aplasia, agenesis, hypoplasia, and dysplasia. A retroviral disease is a highly common thing, and commonly, three retroviruses affect humans. [PubMed: 20984673] [PubMed: 7544896] Renal ultrasound examination of parents in dominantly inherited renal adysplasia: a note of caution. [PubMed: 5539818, related citations] [Full Text: https://doi.org/10.1001/archpedi.1971.02100120096015], Roodhooft, A. M., Birnholz, J. C., Holmes, L. B. But what are those loathsome nucleotides actually doing to him? 2016 Fall;31(2):221-234. The Amazing Spider-Man 2 juggles many plot threads, like a disease that plagues Harry Osborn, but what is the "Osborn Curse," and how did he fix it? Europ. The mutant mice showed severe deficits in kidney morphogenesis due to reduced growth of the ureteric bud toward the metanephric mesenchyme, reduced branching of the ureteric epithelium within the mesenchyme, and defective epithelialization of kidney mesenchymal cells. Soubor cookie je nastaven na zklad souhlasu s cookie GDPR k zaznamenn souhlasu uivatele pro soubory cookie v kategorii Funkn. Ty financujeme jak vlastnmi prostedky, tak penzi od investor, jim prostednictvm dluhopis pinme zajmav zhodnocen jejich aktiv. Managing acute T-cell leukemia due to HTLV1 often involves chemotherapy or hematopoietic stem cell transplants. Dal nekategorizovan soubory cookie jsou ty, kter jsou analyzovny a dosud nebyly zaazeny do dn kategorie. When the nanotubes are adhered to the silk with a drop of water, the resulting combination transmits a current much like a conduit. J. Med. Before McCoy could go public with his discovery, he needed to figure out exactly what syncytin did, a job he passed to bench scientist Sha Mi, who everyone called Misha. The idea that a symbiotic virus or any symbiotic relationship could have such a profound influence on the evolution of a new species is both new and controversial. Hereditary renal adysplasia. In the film we see that Norman Osborn tells his son Harry that the Alissa Anne McCrea 4mo ago 3 Rating Similar questions What is simarine? WebRetroviruses (or, more correctly, retroviridae) are a specific type of virus that contain Reverse transcriptase, a special enzyme that can create DNA from RNA. Mothers can also transmit the virus to their child through breastfeeding. (1982) reported ultrasonographic findings of fetuses with severe kidney disease from 23 families. To the virus, however, infection is an opportunity to unleash its incredible genome copying abilities. [Full Text], Kohn, G., Borns, P. (1985) observed 134 cases of bilateral renal agenesis (BRA), 34 cases of unilateral agenesis with dysplasia of the other kidney (URA/RD), 42 cases of bilateral renal dysplasia (BRD), and 11 cases of renal aplasia. Humbert et al. The association of bilateral renal aplasia in the same family. [PubMed: 4744207] Science 1 What is apolstery? Look no further than Australias koalas. Genetics, pathoanatomy and prenatal diagnosis of Potter I syndrome and other urogenital tract diseases. Centrabl. 63: 239-240, 2003. Anat. 51: 885-888, 1946. J. Pediat. As they moved northward, toward the city of Cairns, they found a similar picture: every koala carried the retrovirus. De novo translocation (1;2)(q32;p25) associated with bilateral renal dysplasia. This review explains the strategy 10 Later, a lymphoproliferative disease, probably causally linked to retroviral insertions into the oncogene LMO-2, developed in 2 patients in an otherwise highly successful gene therapy trial. This drug eliminates up to 99% of the HIV virus within 3 weeks of treatment. If an HIV infection isnt managed through medication, a person can develop acquired immunodeficiency syndrome (AIDS). A pedigree study of perinatally lethal renal disease. Familial renal agenesis and total dysplasia. Even tiny shifts to the timing of certain developmental events could create large changes. The 4.5% frequency of renal agenesis was contrasted with the 0.3% frequency among 682 adults (p less than 0.004). The highest frequency in sibs (8%) was observed when the index case had BRA and urogenital defects. Scott and Goodburn (1995) found no renal malformations in 50% of autopsied second- or third-trimester fetuses with features of Potter syndrome. WebRenal hypodysplasia/aplasia belongs to a group of perinatally lethal renal diseases, including bilateral renal aplasia, unilateral renal agenesis with contralateral dysplasia (URA/RD), and J. Pediat. [PubMed: 6694189] The results were promising and continued to be funded because Osborn made deals with foreign organizations to turn his work into weapons. J. Med. [Full Text], Potter, E. L. [PubMed: 7544896, related citations] In humans, even the most recent of these infiltrations happened tens of thousands of years ago. Comic Books 2011 - 2022 AIPT, LLC. What happens when we mix the two? [PubMed: 12694239] Unfortunately, the only conclusion drawn was Norman's deathand a collection of enemies like the Lizard and Electro, who all have ties to the company. [Full Text: https://doi.org/10.1016/s0092-8674(00)81903-0], Potter, E. L. ART can help to reduce viral load in a person with HIV. There are three genome sequenced and identified exogenous retroviruses of this genus which include two known types (WEHV-1 and WEHV-2) associated with walleye epidermal hyperplasia disease. [Full Text], Rizza, J. M., Downing, S. E. V plnu mme ti developersk projekty v hodnot 300 milion korun. 60: 1-8, 1934. Housny AEDMS, Azab MM, El Bahnasawy MMM, Hassan A, Mohamed AR. Zakldme si na tom, e vechno, co dlme, dlme poctiv. Goblin Disease is a rare, genetic, incurable disease which the character Harry Osborn is diagnosed with and was passed onto him by his father, Norman Osborn, who died from it. Bilateral renal agenesis in three consecutive siblings. [Full Text], Muller, U., Wang, D., Denda, S., Meneses, J. J., Pedersen, R. A., Reichardt, L. F. Reality Check Kliknutm na Pijmout ve souhlaste s pouvnm VECH soubor cookie. As it advances, the rashes reveal green scaly skin, clawed hands and sharpened teeth. We dont really know the chemical composition of our heros sticky homebrew, but if its anything like the real silk from a spiders ass, the answer is maybe. WebRetroviral hypodysplasia is a fictional disease described in the Amazing Spiderman 2 movie. Expert curators AMA Arch. 153: 471, 1994. [PubMed: 12984947], Schmidt, W., Schroeder, T. M., Buchinger, G., Kubli, F. [Full Text: https://doi.org/10.1111/j.1399-0004.1982.tb01422.x], Scott, R. J., Goodburn, S. F. [PubMed: 14171064, related citations] Sequencing technologies had advanced to the point where scientists were incorporating gene discovery into even the most basic research. Its changing how we think of ourselves as a species. Either way, electrons alone arent what make the things go boom. However, for the past two decades retroviruses have been harnessed as vehicles for transferring genes into eukaryotic cells, a process known as transduction. Path. The mutation, which was found in the first fetus by whole-exome sequencing, was confirmed by Sanger sequencing. It also serves as a barrier to prevent infection and keep maternal and fetal blood separate. It contains a nucleocapsid, reverse-transcriptase, integrase, capsid, protease, envelope and surface units. WebThe specific association of retroviral infection with proliferative lesions in fish is based on the presence of retrovirus-like particles (observed via electron microscopy) and reverse J. Hum. We avoid using tertiary references. Norman suffers from something he calls retroviral hypodysplasia, and warns that the junior Osborn will suffer his same fate if a cure is not found. [Full Text: https://doi.org/10.1007/BF00440537], Cain, D. R., Griggs, D., Lackey, D. A., Kagan, B. M. 21: 153-165, 1985. Following the infections as they happen, as well as having an animal model on which to test hypotheses, will likely help us understand how these symbiotic viruses came to play such a powerful role in our own evolution. Everything You Need to Know About Viral Rashes, FDA Panel Recommends Approval of First RSV Vaccine: What to Know, CDC Says Flu Shot Was Effective for Many Adults and Most Kids: What to Know, COVID-19 Pandemic: A 3-Year Retrospective on Masks, Vaccines, and Immunity, Norovirus: Why Cases are on The Rise and How to Avoid It, Can Bird Flu Infect People? Experts Answer Questions About the Outbreak, the type of genetic material they use (DNA or RNA), the method they use to replicate within the cell. As the embryo got larger, viral activity dropped dramatically, though it still continued in specific groups of cells as the fetus developed. Instead, a retrovirus had embedded itself in the koalas germline and passed from parent to child. J. Norman suffers from something he calls retroviral hypodysplasia, and warns that the junior Osborn will suffer his same fate if a cure is not found. HTLV1 is associated with the development of acute T cell leukemias. RELATED:Morbius: Everything You Need To Know About The Living Vampire Before The Film. Muller et al. Advertisements Harry Osborn/Green Goblin Dane DeHaan Image: Sony Pictures/Columbia Pictures/Marvel Entertainment Harry Osborn is a childhood friend of Peter Parker, but the We know that theyre active. 29: 695-696, 1988. Newborn after prolonged leakage of liquor amnii. component of our efforts to ensure long-term funding to provide you the Harry was now Oscorp's CEO and was soon reunited with his childhood friend. Cell 88: 603-613, 1997. Genetics, pathoanatomy and prenatal diagnosis of Potter I syndrome and other urogenital tract diseases. Reklamn soubory cookie se pouvaj k poskytovn relevantnch reklam a marketingovch kampan nvtvnkm. Whatever Normans got is obviously debilitating, and degenerative, so a hereditary retroviral disorder is not too far beyond the bounds of credibility. We know that theyre important, but we still dont know exactly what they do, he says. J. Pediat. In his spare time, he could be found working on his bookstagram, collecting figures, reading comics or watching movies with his girlfriend. The results of this proof-of-concept experiment with marked TIL cells, first performed on a 52-year-old truck driver from Early in the film, we are introduced to Spider-Mans main four-color adversary, Norman Osborn, who in this celluloid version promptly expires, allowing son Harry to pioneer the franchises Green Goblin role. [PubMed: 5634940, related citations] Am. Bilateral renal agenesis in three consecutive siblings. Integrin alpha 8 recessive mutations are responsible for bilateral renal agenesis in humans. In contrast to current anti retroviral drugs which merely suppress the virus. Clin. WhenThe Amazing Spider-Man hit theaters, it not only had to match wits with the Marvel Cinematic Universe, it also had to separate itself from Sam Raimi's trilogy. But with tens of thousands of viruses embedded in our genomes, scientists have only just begun to explore their potential effects. medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions. Integrin alpha-8/beta-1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Zhodnotme mal, vt i velk prostedky prostednictvm zajmavch projekt od rodinnch devostaveb po velk rezidenn a bytov domy. But generally, the main difference between the two is how they replicate within a host cell. Bilateral agenesis of the kidneys in two consecutive infants. Symbiosis was responsible for some of the most significant evolutionary leaps in the history of the planet. Please join your colleagues by making a (Abstract) Am. Further experiments showed that HERVH-derived RNAs are also required to turn adult cells back into pluripotent stem cells. [Full Text], Winter, J. S. D., Kohn, G., Mellman, W. J., Wagner, S. A jde o investice a developersk projekty, poctiv devostavby nebo teba uzeniny a lahdky. J. Obstet. 115: 111-129, 1973. (1973) coined the term hereditary renal 'adysplasia,' which combines the terms aplasia and dysplasia. WebRetroviruses are viruses that inject DNA into cells and the cells begin thinking it is the legitimate DNA. But far from being detrimental, HERV-K activates key genes that help transform a single cell into a fully-formed infant. Z nich se ve vaem prohlei ukldaj soubory cookie, kter jsou kategorizovny podle poteby, protoe jsou nezbytn pro fungovn zkladnch funkc webu. In a final act of desperation, Harry storms Oscorp with Electro, hoping to get a sample of the spider venom Norman and Richard worked on. Genomic disorders were detected in 22.5% of individuals with multiple malformations and 14.5% of individuals with isolated urinary tract defects; 14 individuals harbored 2 or more diagnostic or rare CNVs. High Park Holdings Brands, Health experts provide answers to frequently asked questions about the bird flu outbreak and the danger it poses to humans. J. Obstet. In the placenta, syncytin performed helped the fetus fuse with its mother. Clin. Uroplakin IIIa The Secret Life of Scientists and Engineers. Learn how to recognize them, the viruses that cause them, and how they're spread, treated, and more. [PubMed: 4797640] The genetic results we see today are the silver linings to what otherwise might have been a deadly epidemic, Feschotte says. Genet. (n.d.). [Full Text]. is retroviral hypodysplasia a real disease. Amazing Spider-Man 2: What Is the Osborn Curse and How Did Harry Fix It? By The Amazing Spider-Man 2, there were multiple plot threads tying to Peter, his family, the Osborns and their legacy at Oscorp, but one plot thread introduced early in the film was quietly explored and rectified as Harry Osborn tries to cure a debilitating disease. retroviral envelope protein that had somehow been captured during evolution and been trained to operate in human biology, McCoy says. To prevent this, adults keep a tight control on HERV-K by switching it off, though this isnt the case in very young embryos, Reijo Pera and Wysocka found. review the literature and organize it to facilitate your work. Bankier et al. Genet. [Full Text], Joss, S., Howatson, A., Trainer, A., Whiteford, M., FitzPatrick, D. R. [Full Text: https://doi.org/10.1034/j.1399-0004.2003.00037.x], Kohn, G., Borns, P. The fallopian tubes and uterus were hypoplastic, but ovaries and female external genitalia were normal. 2 10120: 0-2287-9600. Efforts include developing an Integrated Laboratory Strengthening Initiative; strengthening surveillance for The utility of zebrafish in screening for The first HERV reported to be associated with MS in the late 1980s was the Multiple Sclerosis-associated retrovirus (MSRV), a member of the HERV-W family [].In addition to HERV-W, an increased expression of HERV-K and HERV-H families in the blood, brain or cerebrospinal fluid (CSF) from people with MS has also been reported by some groups [], but not others [].The literature on this What is retroviral hyperplasia keyword after analyzing the system lists the list of keywords related and the list of websites with related content, in addition you can see which keywords most interested customers on the this website.

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