venofer dosing calculator10 marca 2023
Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). Applies only to oral form of both agents. Venofer is given as an infusion into a vein. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. These can be input in g/dL, g/L or mmol/L. commonly, these are "non-preferred" brand drugs. Minor/Significance Unknown. May increase risk of hypotension. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. Applies only to oral form of both agents. Anemia. Initial infusion rate. Minor/Significance Unknown. This drug is available at a higher level co-pay. Available for Android and iOS devices. Use Caution/Monitor. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Kidney Int. Administer Venofer early during the dialysis session (generally within the first hour). DOSAGE AND ADMINISTRATION: The recommended dose of Feraheme is an initial 510 mg dose followed by a second 510 mg dose 3 to 8 days later. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. . Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Use Caution/Monitor. Corrected Calcium. Deferasirox chelates iron. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. Medicinal forms Separate by 2 hr. Applies only to oral form of both agents. The elemental iron product used is Iron sucrose 20 mg/mL. Use Caution/Monitor. Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week. Anaphylaxis may occur with IV iron and resuscitation facilities should be available.11 It would appear that iron polymaltose may have a higher incidence of severe systemic reactions than iron sucrose and ferric carboxymaltose. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. Applies only to oral form of both agents. Read our. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . This site complies with the HONcode standard for trust- worthy health information: verify here. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. 2. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. Comparable efficacy to that of IV iron sucrose. Administer Venofer early during the dialysis session (generally within the first hour). The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Iron replenishment can be done intravenously, either as total dose (example: iron-dextran or iron carboxymaltose) or as split dose (example: iron sucrose). Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. We comply with the HONcode standard for trustworthy health information. Parenteral iron dextran therapy. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Use Caution/Monitor. Minor/Significance Unknown. 1996 Aug;11(4):139-46. Applies only to oral form of both agents. Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, eds. 1995 Mar-Apr;11(2):163-8. Do not double the dose to catch up. Applies only to oral form of both agents. Use Caution/Monitor. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. Before using, check this product visually for particles or discoloration. Applies only to oral form of both agents. Use Caution/Monitor. Otherwise, call a poison control center right away. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. [. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Prior to and at regular intervals during parenteral iron therapy, evaluate serum iron, hemoglobin, and hematocrit. Applies only to oral form of both agents. Venofer treatment may be repeated if necessary. Do not administer Venofer to patients with evidence of iron overload. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Each costs about $0.46 to $0.55 per mg of iron. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Ganzoni AM. Applies only to oral form of both agents. Each mL contains 20 mg of elemental iron. This drug is available at a middle level co-pay. Use Caution/Monitor. Avoid or Use Alternate Drug. The dose of Venofer must be individually calculated for each patient according to the total iron deficit calculated with the following Ganzoni formula, for example: Total iron deficit [mg] = BW [kg] x (target Hb - actual Hb) [g/dl] x 2.4* + storage iron [mg] Below 35 kg BW: 35 kg BW and above: Target Hb = 13 g/dl and storage iron = 15 mg/kg BW Contraindicated. Contact the applicable plan There is in depth information below the form on the method used and on the result provided. iron sucrose decreases levels of ibandronate by inhibition of GI absorption. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. Most Use Caution/Monitor. Minor (1)iron sucrose, benazepril. Do not mix iron sucrose with other medications or TPN solution. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. Methods. Avoid or Use Alternate Drug. Interaction only with oral iron administration. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Modify Therapy/Monitor Closely. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Modify Therapy/Monitor Closely. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Venofer [package insert]. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Human studies not conducted. Diagnosis and management of iron deficiency anaemia: a clinical update. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. Applies only to oral form of both agents. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. For additional Safety Information, please see Full Prescribing Information. Sodium ferric gluconate (Ferrlecit) 62.5 mg . Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. Creating an account is free and takes less than 1 minute. STORAGE: Consult the product instructions and your pharmacist for storage details. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Uses for Iron Sucrose Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. INFED- iron dextran injection [Package insert], Hemoglobin iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) Note: Hbg (current hemoglobin level) units: (g/dL) Alternatively: Volume of product required (mL) = [weight (kg) x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Chandler G, Harchowel J, Macdougall I. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. iron sucrose increases levels of calcium gluconate by enhancing GI absorption. FERAHEME met the predefined criteria for non-inferiority to Venofer . Applies only to oral form of both agents. Copyright 2021 GlobalRPH - Web Development by. (2010) Diagnosis and management of iron deficiency anaemia: a clinical update. This cost includes the fee charged by the pharmacy. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. Use Caution/Monitor. Applies only to oral form of both agents. 2010; 193(9):525-32. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Applies only to oral form of both agents. Do Not Copy, Distribute or otherwise Disseminate without express permission. UpToDate. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. Use Caution/Monitor. Drug Des Devel Ther; 5: 5160. Minor/Significance Unknown. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. 1. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Give each dose as 15 mg/kg body weight for a total cumulative dose not to exceed 1500 mg of iron per course. calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Individual plans may vary Accessed: 4/12/2011. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. The primary endpoint was the proportion of patients with . IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established.
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