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Multicenter trial of L-carnitine in maintenance hemodialysis patients. Clin Ther 1995;17:176-85. 2012;11:CD008394. View abstract. But doses of less than 3 grams a day seem safe for pretty much anyone. View abstract. Waldner, R., Laschan, C., Lohninger, A., Gessner, M., Tuchler, H., Huemer, M., Spiegel, W., and Karlic, H. Effects of doxorubicin-containing chemotherapy and a combination with L-carnitine on oxidative metabolism in patients with non-Hodgkin lymphoma. Oncologist. Sugino, T., Aoyagi, S., Shirai, T., Kajimoto, Y., and Kajimoto, O. Hollyer T, Boon H, Georgousis A, et al. Protective effect of acetyl-L-carnitine on the apoptotic pathway of peripheral . Effects of L-carnitine supplementation on the quality of life in diabetic patients with muscle cramps. Xie, J., Zeng, Q., and Wang, L. The protective effect of L-carnitine on ischemia-reperfusion heart. View abstract. Can.J Public Health 2008;99(4):276-280. View abstract. 2006;26(4):499-500. Taking too much (2 to 3 grams . J Inherit.Metab Dis 1-7-2008; View abstract. Passeri M, Cucinotta D, Bonati PA, et al. Fornasini, G., Upton, R. N., and Evans, A. M. A pharmacokinetic model for L-carnitine in patients receiving haemodialysis. However, popular claims about supplements dont always match up with the science. Information from this source is evidence-based and objective, and without commercial influence. Gesuete, V., Ragni, L., and Picchio, F. M. [The "big heart" of carnitine]. A., Borum, P., Stall, C., Millspaugh, J., Taggart, E., and Lum, G. Carnitine status of pediatric patients on continuous ambulatory peritoneal dialysis. One study of people with type 2 diabetes taking anti-diabetic medication indicated that carnitine supplements significantly reduced blood sugar levels, compared to a placebo (55). Clin Nutr 2012;31(2):176-182. Bolognesi, M., Amodio, P., Merkel, C., Godi, L., and Gatta, A. Pickard, R. Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. Kidney Int 38 (1990): 904-11, 4. L-carnitine may also reduce symptoms of type 2 diabetes and its associated risk factors (52, 53, 54). Eat these 11 foods to boost your memory and focus, help prevent disease, and keep sharp as you. View abstract. Muscle carnitine deficiency associated with zidovudine-induced mitochondrial myopathy. J Intern.Med. Pugliese, D., Sabba, C., Ettorre, G., Berardi, E., Antonica, G., Godi, L., Palasciano, G., Lee, S. S., and Albano, O. Complement Ther Med 2011;19(4):216-227. Drugs Exper Clin Res 1983;9:925-934. Warfarin is used to slow blood clotting. Szymanski M, Wandtke T, Wasilow K, Andryszczyk M, Janicki R, Domaracki P. Comparison of 3- and 6-Month Outcomes of Combined Oral L-Carnitine Fumarate and Acetyl-L-Carnitine Therapy, Included in an Antioxidant Formulation, in Patients with Idiopathic Infertility. Schweiz.Med Wochenschr 9-12-1992;122(37):1352-1355. [Short-term medication of L-carnitine before intracytoplasmic sperm injection for infertile men with oligoasthenozoospermia]. 39. View abstract. Dutta, A., Ray, K., Singh, V. K., Vats, P., Singh, S. N., and Singh, S. B. L-carnitine supplementation attenuates intermittent hypoxia-induced oxidative stress and delays muscle fatigue in rats. Wang, J. and Wang, X. 2008;47(10):823-825. 2013 Sep;67(7):659-63. Fujiwara, M., Nakano, T., Tamoto, S., Yamada, Y., Fukai, M., Takada, K., Ashida, H., Shimada, T., Ishihara, T., and Seki, I. Karimi, M., Mohammadi, F., Behmanesh, F., Samani, S. M., Borzouee, M., Amoozgar, H., and Haghpanah, S. Effect of combination therapy of hydroxyurea with l-carnitine and magnesium chloride on hematologic parameters and cardiac function of patients with beta-thalassemia intermedia. View abstract. Am J Clin Nutr 2007;86:1738-44. J Inherit.Metab Dis 9-10-2010; View abstract. View abstract. J.Reprod.Infertil 2010;10(4):245-251. A single-center prospective pilot study. Vecchiet L, Di Lisa F, Pieralisi G, et al. Brand names: Carnitor, L-Carnitine Rolim LC, da Silva EM, Flumignan RL, Abreu MM, Dib SA. View abstract. Studies concerning chronic and acute effects of L-carnitine on some biological parameters in elite athletes. View abstract. 2020;42(6):386-390. Jacobs, P. L., Goldstein, E. R., Blackburn, W., Orem, I., and Hughes, J. J. Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. It can also cause a "fishy" odor of the urine, breath, and sweat. [L-carnitine: safe and effective for asthenozoospermia]. 2010;32(9):1109-1114. 1988;192(4):155-157. Gramignano, G., Lusso, M. R., Madeddu, C., Massa, E., Serpe, R., Deiana, L., Lamonica, G., Dessi, M., Spiga, C., Astara, G., Maccio, A., and Mantovani, G. Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy. View abstract. The effects of L-carnitine supplementation on lipid concentrations inpatients with type 2 diabetes: A systematic review and meta-analysis of randomized clinical trials. Ruggenenti, P., Cattaneo, D., Loriga, G., Ledda, F., Motterlini, N., Gherardi, G., Orisio, S., and Remuzzi, G. Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapy. View abstract. View abstract. De Vecchi, A. F., Arduini, A., Di, Liberato L., and Bonomini, M. [L-carnitine in peritoneal dialysis]. Park, H. D., Kim, S. R., Ki, C. S., Lee, S. Y., Chang, Y. S., Jin, D. K., and Park, W. S. Two novel HADHB gene mutations in a Korean patient with mitochondrial trifunctional protein deficiency. View abstract. View abstract. Minerva Urol.Nefrol. View abstract. Patrikarea A, Stamatelow K Ntaountaki I Papadakis IT. Jung, J., Eo, E., and Ahn, K. O. View abstract. Caruso U, Cravotto E, Tisone G, and et al. Endocr.J 2010;57(9):777-786. Effects of high carnitine supplementation on substrate utilization in low-birth-weight infants receiving total parenteral nutrition. However, several studies note mild benefits associated with larger or more long-term doses (43, 44, 45). Effect of dialysate composition on the lipid response to L-carnitine supplementation. Side Effects. Am.J Clin Oncol. Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract in vitro by HPLC-DAD and HPLC-ESI/MS analyses. Lancet 12-13-1980;2(8207):1309-1310. Signorelli, S. S., Fatuzzo, P., Rapisarda, F., Neri, S., Ferrante, M., Oliveri, Conti G., Fallico, R., Di, Pino L., Pennisi, G., Celotta, G., and Massimiliano, A. View abstract. It can also cause a "fishy" odor of the urine, breath, and sweat. View abstract. Young, P., Finn, B. C., Alvarez, F., Bruetman, J. E., and Trimarchi, H. [Valproate-associated hyperammonemic encephalopathy. Sekas G, Paul HS. Levocarnitine-induced hypophosphatemia in a hemodialysis patient with acute valproic acid toxicity. Ahmad S, Robertson HT, Golper TA, et al. Am.J Clin Nutr. L-carnitine supplements can incur side effects similar to those of most dietary supplements and medications. Clinical Trials Journal 1986;23(6):338-344. Hatamkhani S, Khalili H, Karimzadeh I, Dashti-Khavidaki S, Abdollahi A, Jafari S. Carnitine for prevention of antituberculosis drug-induced hepatotoxicity: a randomized, clinical trial. Derosa, G., Maffioli, P., Salvadeo, S. A., Ferrari, I., Gravina, A., Mereu, R., D'Angelo, A., Palumbo, I., Randazzo, S., and Cicero, A. F. Effects of combination of sibutramine and L-carnitine compared with sibutramine monotherapy on inflammatory parameters in diabetic patients. View abstract. El-Metwally, T. H., Hamed, E. A., Ahmad, A. R., and Mohamed, N. A. Dyslipidemia, oxidative stress and cardiac dysfunction in children with chronic renal failure: effects of L-carnitine supplementation. Fertil.Steril 2003;80(Suppl 3):48. Effect of L-carnitine supplement on semen parameters in men with idiopathic infertility. Rossignol, D. A. and Frye, R. E. Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. Srivastava DK, Kumar S Misra AP. Dal Lago A, De Martini D, Flore R, et al. Diarrhea View abstract. Martinez E, Domingo P, Roca-Cusachs A. Potentiation of acenocoumarol action by L-carnitine. 2014 Jun;63(6):996-1004. 2011;21(6):485-491. Diabetes Nutr Metab Clin Exp 1992;5(3):175-181. Plasma and urine carnitine concentrations in well-trained athletes at rest and after exercise. Three-year survival of patients with heart failure caused by dilated cardiomyopathy and L-carnitine administration. Physiologie. Iliceto S, Scrutinio D, Bruzzi P, et al. Golper, T. A., Wolfson, M., Ahmad, S., Hirschberg, R., Kurtin, P., Katz, L. A., Nicora, R., Ashbrook, D., and Kopple, J. D. Multicenter trial of L-carnitine in maintenance hemodialysis patients. Valcour, V., Yeh, T. M., Bartt, R., Clifford, D., Gerschenson, M., Evans, S. R., Cohen, B. 1990;5(3):263-265. View abstract. Follow all directions on your medicine label and package. Sun, Z. J., Yang, C. B., Wang, H., and Li, Y. "Product Information. J Perinatol. 2013 Apr;121(4):234-8. 2008;28(8):495-500. 2010;16(10):919-921. Vicari E, La Vignera S, Calogero AE. 1998;32(2):258-264. New Trends Clin Neuropharmacol 1989;3(4):225-230. Mov Disord. J Mol.Histol. View abstract. Saturated fat 10 and added sugars are linked to a myriad of health problems such as heart disease, type 2 diabetes, and obesity. J Pediatr.Gastroenterol.Nutr. All rights reserved. View abstract. According to the University of Maryland Medical Center, carnitine is successful in treating hyperthyroidism possibly because of its ability to block the effects of thyroid hormones - a potentially dangerous effect for people suffering from an underactive thyroid. View abstract. 2006;12(5):261-262. Circ.J 2008;72(6):926-931. Schulte RR, Madiwale MV, Flower A, et al. New Trends Clin Neuropharmacol 1989;3(1):17-24. Lenzi A, Sgro P, Salacone P, et al. Early Hum.Dev. The effect of enteral carnitine administration in humans. Lipids Health Dis. Lancet 10-14-1978;2(8094):805-807. View abstract. View abstract. Effect of glycine propionyl-L-carnitine on aerobic and anaerobic exercise performance. Biomed Pharmacother. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Clin Neuropharmacol. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Brain Dev. 7-14-2009;89(26):1858-1861. Ageing Res.Rev. 2010;16(1):5-14. Unexpected awakening from comatose thyroid storm after a single intravenous injection of L-carnitine. Paediatr Drugs. Williams, S. F., Alvarez, J. R., Pedro, H. F., and Apuzzio, J. J. Glutaric aciduria type II and narcolepsy in pregnancy. The effects of L-carnitine supplementation on glycemic control: a systematic review and meta-analysis of randomized controlled trials. View abstract. Australas Psychiatry. Castro-Gago M, Eiris-Punal J, Novo-Rodriguez MI, et al. Preventive effect of L-carnitine on scar formation during acute pyelonephritis: A randomized placebo-controlled trial. View abstract. 2004;97(2):c41-c48. Youle, M. Acetyl-L-carnitine in HIV-associated antiretroviral toxic neuropathy. 2010;32(8):669-672. B., Lagler, F., Maier, E. M., Schwahn, B., Tokatli, A., Dursun, A., Coskun, T., Chalmers, R. A., Koeller, D. M., Zschocke, J., Christensen, E., Burgard, P., and Hoffmann, G. F. Natural history, outcome, and treatment efficacy in children and adults with glutaryl-CoA dehydrogenase deficiency. [Values of tandem mass spectrometry in etiologic diagnosis of cerebral developmental retardation]. Clin Ther 2010;32(4):710-713. View abstract. Pettegrew JW, Klunk WE, Panchalingam K, et al. View abstract. 2-15-1981;96(3):263-270. View abstract. Efficacy and safety of entecavir plus carnitine complex (GODEX) compared to entecavir monotherapy in patient with ALT elevated chronic hepatitis B: Pediatr.Endocrinol.Diabetes Metab 2010;16(2):78-81. How can you boost your metabolism? View abstract. Scand.J Gastroenterol. Acetyl-L-carnitine in the treatment of mildly demented elderly patients. Baghban F, Hosseinzadeh M, Mozaffari-Khosravi H, Dehghan A, Fallahzadeh H. The effect of L-Carnitine supplementation on clinical symptoms, C-reactive protein and malondialdehyde in obese women with knee osteoarthritis: a double blind randomized controlled trial. There are several effective supplements that can help you burn body fat. 2010;33(2):132-136. J Nephrol. Gastrointestinal J Pediatr 1982;101:782-5. J Am Coll Nutr 1999;18:77-82. Lu, S. M., Li, X., Zhang, H. B., Hu, J. M., Yan, J. H., Liu, J. L., and Chen, Z. J. Crentsil, V. Mechanistic contribution of carnitine deficiency to geriatric frailty. Cherchi A, Lai C, Onnis E, et al. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to levocarnitine: injectable solution, oral capsule, oral solution, oral tablet. Acta Neurol.Scand. View abstract. Volek, J. S., Judelson, D. A., Silvestre, R., Yamamoto, L. M., Spiering, B. Am J Cardiol 1994;74:125-30. Laker MF, Green C, Bhuiyan AK, Shuster S. Isotretinoin and serum lipids: studies on fatty acid, apolipoprotein and intermediary metabolism. View abstract. Sethumadhavan, S. and Chinnakannu, P. Carnitine and lipoic acid alleviates protein oxidation in heart mitochondria during aging process. Medicine (Baltimore). 2007;45(7):513-517. Beneficial effects of L-carnitine in myoblastic C2C12 cells. Rossignol, D. A. Cruciani, R. A., Dvorkin, E., Homel, P., Culliney, B., Malamud, S., Lapin, J., Portenoy, R. K., and Esteban-Cruciani, N. L-carnitine supplementation in patients with advanced cancer and carnitine deficiency: a double-blind, placebo-controlled study. Serati AR, Motamedi MR, Emami S, et al. Ren Fail. Rossini, D., Bulckaen, M., Di, Marco S., Giovannetti, R., Giuntoli, F., Lacopetti, L., and Vergoni, W. [Rehabilitation program in patients with moderate-to-severe intermittent claudication: immediate results and one year follow-up]. Bohmer, T., Boen, A., and Hoymork, S. C. Valproate-induced hyperammonemic encephalopathy, rapidly improved by i.v. View abstract. Effects of L-carnitine supplementation on physical performance and energy metabolism of endurance-trained athletes: a double-blind crossover field study. 2011;(12):CD006282. 2007;178(4 Pt 1):1398-1403. Specific populations may benefit from L-carnitine supplements. Sabry, A. 1990;34(6):501-505. Int J Clin Pharmacol Res 1990;10:101-7. Spagnoli A, Lucca U, Menasce G, et al. J Ren Nutr 1998;8:118-21. Carlsson, M., Forsberg, E., and Thorne, A. Observations during L-carnitine infusion in two long-term critically ill patients. In one study, 2 grams of acetyl-L-carnitine per day resulted in an almost 10-point drop in systolic blood pressure the top number of a blood pressure reading and an important indicator of heart health and disease risk (23). Ann Pharmacother 2000;34:630-8. 1997;37(3 Pt 1):491-493. Ann.Indian Acad.Neurol. View abstract. Reprod.Biomed.Online. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. View abstract. Int J Clin Pharmacol Res 1988;8(5):367-376. View abstract. View abstract. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. A pilot study on aging skeletal muscle mass and function. Don't use CoQ10 if you're pregnant or breast-feeding without your doctor's approval. Drugs 1999;58:479-87. Goldenberg, N. A., Krantz, M. J., and Hiatt, W. R. L-Carnitine plus cilostazol versus cilostazol alone for the treatment of claudication in patients with peripheral artery disease: a multicenter, randomized, double-blind, placebo-controlled trial. [L-carnitine and cardiac metabolism and remodeling indices in alcoholic cardiomyopathy]. Zhang, Y., Song, J. Q., Liu, P., Yan, R., Dong, J. H., Yang, Y. L., Wang, L. F., Jiang, Y. W., Zhang, Y. H., Qin, J., and Wu, X. R. [Clinical studies on fifty-seven Chinese patients with combined methylmalonic aciduria and homocysteinemia]. Clin Pharmacokinet 2003;42:941-67. Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging. Kumar, A., Singh, R. B., Saxena, M., Niaz, M. A., Josh, S. R., Chattopadhyay, P., Mechirova, V., Pella, D., and Fedacko, J. Ammonia and carnitine concentrations in children treated with sodium valproate compared with other anticonvulsant drugs. BMC Comp Altern Med 2002;2:5. 2010;15(2):200-211. Askarpour M, Hadi A, Symonds ME, et al. Anesth.Analg. View abstract. Bartels GL, Remme WJ, Holwerda KJ, Kruijssen DA. View abstract. Abbasnezhad A, Hasanavand A, Falahi E, Kashkooli S, Asbaghi O, Choghakhori R. Effect of L-carnitine supplementation on lipid profiles of patients with liver disease: a systematic review and meta-analysis. Ricci, A., Caiati, C., Galantino, A., Scrutinio, D., Valentini, G., Chiddo, A., and Rizzon, P. [Acute effects of propionyl-L-carnitine on anomalies of parietal kinetics of the left ventricle induced by atrial pacing in patients with ischemic heart disease. 2008;23(7):1602-1606. Efficacy of l-carnitine supplementation for management of blood lipids: A systematic review and dose-response meta-analysis of randomized controlled trials. 1993;25(6):733-740. 2005;28(2):141-152. Cochrane.Database.Syst.Rev. It's been theorised that L-carnitine could help your body to produce energy by utilising the body's fat stores, allowing you to work out for longer and ultimately aiding in fat loss. The effect of L-carnitine supplement on dialysis patients [abstract]. Weinhandl, E. D., Rao, M., Gilbertson, D. T., Collins, A. J., and Pereira, B. J. Kobulia B, Chapichadze Z Andriadze G Machavariani P. Effects of carnitine on 6-month incidence of mortality and heart failure in patients with acute myocardial infarction. All rights reserved. The brain, inflammation and you Inflammation intimately affects sleep quality, especially in older adults. L-carnitine and Vitamin B Complex for the Treatment of Pegasparaginase-induced Hyperbilirubinemia. View abstract. Maestri, A., De Pasquale, Ceratti A., Cundari, S., Zanna, C., Cortesi, E., and Crino, L. A pilot study on the effect of acetyl-L-carnitine in paclitaxel- and cisplatin-induced peripheral neuropathy. Abbasnezhad A, Choghakhori R, Kashkooli S, Alipour M, Asbaghi O, Mohammadi R. Effect of L-carnitine on liver enzymes and biochemical factors in hepatic encephalopathy: A systematic review and meta-analysis. View abstract. I fell asleep at night but woke up repeatedly and then couldn't get back to sleep. Am J Clin Nutr 1981;34(8):1496-1500. It is unlikely to cause significant weight loss. Acenocoumarol is used to slow blood clotting. Asbaghi O, Kashkooli S, Amini MR, et al. 2006;25(6):886-896. It may also combat diabetes by increasing a key enzyme called AMPK, which improves your bodys ability to use carbs (56). Hemodial.Int. View abstract. 2008;8:365. Int.J Sport Nutr.Exerc.Metab 2008;18(1):19-36. Shojaei, M., Djalali, M., Khatami, M., Siassi, F., and Eshraghian, M. Effects of carnitine and coenzyme Q10 on lipid profile and serum levels of lipoprotein(a) in maintenance hemodialysis patients on statin therapy. Bella R, Biondi R, Raffaele R, Pennisi G. Effect of acetyl-L-carnitine on geriatric patients suffering from dysthymic disorders. J Anal Toxicol 1996;20:55-8. L-carnitine supplementation for the management of fatigue in patients with cancer: an eastern cooperative oncology group phase III, randomized, double-blind, placebo-controlled trial. Miwa, S. and Takikawa, O. Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's Disease. The effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation in migraine prophylaxis. Metabolism 2007;56(8):1118-1123. Urology 2004;63:641-6. Effects of L-carnitine administration on VO2max and the aerobic- anaerobic threshold in normoxia and acute hypoxia. View abstract. Giamberardino, M. A., Dragani, L., Valente, R., di Lisa, F., Saggini, R., and Vecchiet, L. Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort. View abstract. Morano, S., Mandosi, E., Fallarino, M., Gatti, A., Tiberti, C., Sensi, M., Gandini, L., Buchetti, B., Lenti, L., Jannini, E. A., and Lenzi, A. Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. L-Carnitine for Thyroid Fatigue. View abstract. Harper, P., Elwin, C. E., and Cederblad, G. Pharmacokinetics of intravenous and oral bolus doses of L-carnitine in healthy subjects. Nebbioso M, Evangelista M, Librando A, Plateroti AM, Pescosolido N. Iatrogenic dry eye disease: an eledoisin/carnitine and osmolyte drops study. View abstract. Murakami K, Sugimoto T, Woo M, et al. Metabolism 2009;58(11):1618-1623. Anti-human immunodeficiency virus (HIV) activitiy, safety, and pharmacokinetics of adefovir dipivoxyl (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients. Alcohol Alcohol 2010;45(5):449-455. J Inherit.Metab Dis 6-15-2010; View abstract. Iyer, R., Gupta, A., Khan, A., Hiremath, S., and Lokhandwala, Y. As a supplement, acetyl-L-carnitine is usually considered safe when taken as directed. Nasser, M., Javaheri, H., Fedorowicz, Z., and Noorani, Z. Carnitine supplementation for inborn errors of metabolism. Dragan, I. G., Vasiliu, A., Georgescu, E., and Eremia, N. Studies concerning chronic and acute effects of L-carnitina in elite athletes. 1986;24(9):511-516. View abstract. View abstract. J Huazhong.Univ Sci Technolog.Med.Sci 2006;26(2):188-191. View abstract. View abstract. I took in the morning at about 9 but had serious trouble sleeping all night that night. Systematic review of pharmacological treatments in fragile X syndrome. Infusionsther.Klin.Ernahr.